CD55 anticorps

N° du produit ABIN5541170

Cet anticorps Rat Monoclonal détecte spécifiquement CD55 dans FACS et WB. Il présente une réactivité envers Souris.

Aperçu rapide pour CD55 anticorps (ABIN5541170)

Antigène: CD55 (Complement Decay-Accelerating Factor (CD55))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD55 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB)

Clone: 3D5

Détail du produit anti-CD55 anticorps

Specificité: The monoclonal antibody 3D5 recognizes complement decay accelerating factor (DAF), also designated as CD55.

Purification: Protein G Chromatography

Immunogène: NRK cells expressing transmembrane-anchored Mouse DAF

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry. Western blot. The typical starting working dilution is 1/50.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CD55

Antigène: CD55 (Complement Decay-Accelerating Factor (CD55))

Autre désignation: cd55,daf

Sujet: Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Mouse DAF (CD55) is a 60 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. DAF is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although DAF does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators DAF protects self cells from autologous complementmediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point.

UniProt: Q61475

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity