MAPT anticorps (pSer202)

N° du produit ABIN5541354

L’anticorps anti-MAPT Polyclonal Lapin est utilisé pour la détection de MAPT dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB.

Aperçu rapide pour MAPT anticorps (pSer202) (ABIN5541354)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MAPT anticorps

Épitope: pSer202

Specificité: The antibody detects endogenous levels of Tau only when phosphorylated at serine 202.

Purification: Affinity chromatography using epitope-specific peptide

Immunogène: Peptide sequence around phosphorylation site of serine 202(P-G-S(p)-P-G) derived from Human Tau (KLH-conjugated)

Information d'application

Indications d'application: Western blot: 1:500~1:1000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: mapt,tau

Sujet: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

UniProt: P10636

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size