ESM1 anticorps (AA 19-184)

N° du produit ABIN5541433

Cet anticorps anti-ESM1 est un anticorps Lapin Polyclonal détectant ESM1 dans WB, ICC, IHC (fro) et IF. Adapté pour Humain.

Aperçu rapide pour ESM1 anticorps (AA 19-184) (ABIN5541433)

Antigène: ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ESM1 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Détail du produit anti-ESM1 anticorps

Épitope: AA 19-184

Specificité: This antibody detects Endocan / ESM1.

Purification: Protein A chromatography

Immunogène: Highly pure (> 95%) recombinant human Endocan/ESM1 (Trp19-Arg184) derived from E. coli

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1-5 μg/mL. Immunofluorescence : 1/200. Immunhistochemistry on Frozen sections : 1:200.

Restrictions: For Research Use only

Stockage

Buffer: 5 mM PBS, pH 7.2

Stock: 4 °C,-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur ESM1

Antigène: ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))

Autre désignation: esm1

Sujet: Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFα, IL1β or lipopolysaccharide and down-regulated by IFNγ. The mouse Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects.

Pathways: Growth Factor Binding