TBX2 anticorps (AA 554-702)

N° du produit ABIN5541456

L’anticorps Souris Monoclonal anti-TBX2 a été validé pour WB, IP et IHC (p). Il convient pour détecter TBX2 dans des échantillons de Humain.

Aperçu rapide pour TBX2 anticorps (AA 554-702) (ABIN5541456)

Antigène: TBX2 (T-Box 2 (TBX2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TBX2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4D6

Détail du produit anti-TBX2 anticorps

Épitope: AA 554-702

Purification: Purified

Immunogène: Derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a GST fusion protein corresponding to residues 554-702 of Human TBX2.

Isotype: IgG1

Information d'application

Indications d'application: Western blot. Immunoprecipitation. Immunohistochemistry on Paraffin Sections.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TBX2

Antigène: TBX2 (T-Box 2 (TBX2))

Autre désignation: tbx2

Sujet: T-box transcription factor TBX2 is a protein that in humans is encoded by the TBX2 gene and with subcellulair location in the nucleus. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor The oncogene TBX2 is a cooperating factor in transformation of pocket protein deficient MEFs. TBX2 downregulates the p53/p21CIP1 pathway both in wild-type and pocket protein deficient MEFs. Tissue specificity: expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

UniProt: Q13207

Pathways: Signalisation p53