LARGE anticorps (AA 35-142)

N° du produit ABIN5541530

Cet anticorps Souris Monoclonal détecte spécifiquement LARGE dans WB et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour LARGE anticorps (AA 35-142) (ABIN5541530)

Antigène: LARGE (Like-Glycosyltransferase (LARGE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LARGE est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: LARGE-02

Détail du produit anti-LARGE anticorps

Épitope: AA 35-142

Specificité: This antibody recognizes human LARGE1, a glycosyltransferase localizing mainly to the Golgi apparatus. Crossreactivity with LARGE2 was not determined.

Purification: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)

Immunogène: Recombinant fragment of human LARGE1 (amino acids 35-142)

Isotype: IgG2b

Information d'application

Indications d'application: Flow cytometry. Western blot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 95 % pure by SDS-PAGE) Buffer System: Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur LARGE

Antigène: LARGE (Like-Glycosyltransferase (LARGE))

Autre désignation: large

Sujet: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.

UniProt: O95461