TWEAK anticorps

N° du produit ABIN5541911

Cet anticorps Souris Monoclonal détecte spécifiquement TWEAK dans FACS et Func. Il présente une réactivité envers Humain.

Aperçu rapide pour TWEAK anticorps (ABIN5541911)

Antigène: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TWEAK est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: CARL-1

Détail du produit anti-TWEAK anticorps

Specificité: This antobody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types.

Purification: Protein-A affinity chromatography

Immunogène: Human CD255-transfected 2PK-3 cells

Isotype: IgG3

Information d'application

Indications d'application: Flow cytometry. Functional application: Neutralization.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TWEAK

Antigène: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Autre désignation: tweak,tnfsf12

Sujet: CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.

UniProt: O43508

Pathways: Apoptose