MASP1 anticorps

N° du produit ABIN5542173

L’anticorps Souris Monoclonal anti-MASP1 a été validé pour WB, IP et EIA. Il convient pour détecter MASP1 dans des échantillons de Humain.

Aperçu rapide pour MASP1 anticorps (ABIN5542173)

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MASP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Clone: 1E2

Détail du produit anti-MASP1 anticorps

Specificité: This Monoclonal 1E2 antibody recognizes the heavy chain common to both MASP-1 and MASP-3.

Purification: Purified

Immunogène: MASP peptide

Isotype: IgG1

Information d'application

Indications d'application: Immuno Assays (Coating antibody). Immunoprecipitation. Western blot (Non Reducing Conditions). The typical starting working dilution is 1/10.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MASP1

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Autre désignation: masp-1/3

Sujet: Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASP) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASP are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP- 1, MASP-2 and MASP-3. MASP-1 appears to cleave the second complement component C2, but not C4. The proteolytic activities of MASP-1 are inhibited by C1-inhibitor. Furthermore MASP-1 has a reactivity profile very similar to that of thrombin. MASP-1 is able to catalyse the formation of cross-linked fibrin. Participation of MASP-1 in crosslinked fibrin clot formation causes release of a chemotactic factor representing a biologically significant activity of MASP-1. The alternative-splicing product from MASP-1 gene is called MASP-3. MASP-1 is associated with smaller MBL oligomers whereas MASP-3 is found on larger oligomers. The substrate of MASP-3 is unknown.

UniProt: P48740

Pathways: Système du Complément