CR1L anticorps

N° du produit ABIN5542182

L’anticorps Rat Monoclonal anti-CR1L a été validé pour EIA. Il convient pour détecter CR1L dans des échantillons de Souris.

Aperçu rapide pour CR1L anticorps (ABIN5542182)

Antigène: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CR1L est non-conjugé

Application: Enzyme Immunoassay (EIA)

Clone: 8A-E6

Détail du produit anti-CR1L anticorps

Specificité: The monoclonal antibody 8A/E6 recognizes Mouse complement receptor type-1 related gene Y (Crry/p65), a type I membrane protein (MW 56-60 kDa).

Purification: Purified

Immunogène: Mouse Crry fused to Mouse IgG2a-Fc

Isotype: IgG1

Information d'application

Indications d'application: Immuno assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CR1L

Antigène: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Autre désignation: cr1l,crry

Sujet: Complement comprises a system of soluble serum proteins that, upon activation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Rat and mouse express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). Crry/p65 is expressed on a wide variety of cells. Crry/p65 contains tandem short consensus repeats (SCR) characteristic of C3/C4 binding proteins. Mouse Crry/p65 has been shown to regulate both classical and alternative complement pathway C3 deposition on cell membranes. Crry/p65 must, therefore, exert its effects prior to, or at the level of, the C3 convertases, in a fashion similar to that of the human membrane factors DAF and MCP. Crry/p65 is an evolutionarily unique, complement regulatory protein which has developed in mouse and rat. Besides the involvement in control of complement damage to cell membranes Crry has also a role in T cell activation. Crry basically enhances the signals triggered by TCR/CD3 activation.

UniProt: Q64735

Pathways: Système du Complément