SMAD1 anticorps (AA 1-110)

N° du produit ABIN5542387

Cet anticorps anti-SMAD1 est un anticorps Souris Monoclonal détectant SMAD1 dans WB et ELISA. Adapté pour Humain, Souris et Singe.

Aperçu rapide pour SMAD1 anticorps (AA 1-110) (ABIN5542387)

Antigène: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Reactivité: Humain, Souris, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMAD1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 4E12H10

Détail du produit anti-SMAD1 anticorps

Épitope: AA 1-110

Fonction: SMAD1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human SMAD1 (AA: 1-110) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur SMAD1

Antigène: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Autre désignation: SMAD1

Sujet: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Poids moléculaire: 52 kDa

UniProt: Q15797

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development