ATG5 anticorps

N° du produit ABIN5542579

Détail du produit anti-ATG5 anticorps

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATG5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Séquence: Synthesize d peptide of human ATG5 (AA: MTDDKDVLRD VWFGRIc).

Immunogène: Synthesized peptide of human ATG5 (AA: MTDDKDVLRDVWFGRIc).

Clone: 8E8G6

Isotype: IgG2a

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur ATG5

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Autre désignation: ATG5 (ATG5 Produits)

Synonymes: anticorps APG5, anticorps APG5-LIKE, anticorps APG5L, anticorps ASP, anticorps hAPG5, anticorps ATG5, anticorps CG1643, anticorps DmAtg5, anticorps Dmel\\CG1643, anticorps atg5, anticorps 2010107M05Rik, anticorps 3110067M24Rik, anticorps AW319544, anticorps Apg5l, anticorps Atg5l, anticorps C88337, anticorps Paddy, anticorps apg5l, anticorps zgc:100934, anticorps ATATG5, anticorps AUTOPHAGY 5, anticorps MKP11.20, anticorps MKP11_20, anticorps autophagy related 5, anticorps Autophagy-related 5, anticorps ATG5 autophagy related 5 homolog (S. cerevisiae), anticorps autophagy related 5 L homeolog, anticorps similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12, anticorps autophagy protein Apg5 family, anticorps ATG5, anticorps Atg5, anticorps atg5, anticorps atg5.L, anticorps APG5

Sujet:

Description: ATG5 involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating, system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential, for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8, family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after, oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the, innate antiviral immune response by blocking the type I IFN production pathway through direct association with, RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation, apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T, lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II., Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte, differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation, of IFT20 via the autophagic pathway,

Aliases: ASP, APG5, APG5L, hAPG5, APG5-LIKE

Poids moléculaire: 32.4 kDa

ID gène: 9474

HGNC: 9474

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy