Kdm6b anticorps (N-Term)

N° du produit ABIN5551987

Détail du produit anti-Kdm6b anticorps

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kdm6b est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody will recognize JMJD3 (N-term).

Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human JMJD3.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western Blot: 1/250-1/500. Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur Kdm6b

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Autre désignation: JMJD3 / KDM6B (Kdm6b Produits)

Synonymes: anticorps jmjd3, anticorps kdm6b, anticorps si:ch211-237l4.7, anticorps 1700064E03Rik, anticorps BC038313, anticorps Jmjd3, anticorps mKIAA0346, anticorps JMJD3, anticorps lysine (K)-specific demethylase 6B, anticorps lysine demethylase 6B, anticorps lysine (K)-specific demethylase 6B, b, anticorps KDM1 lysine (K)-specific demethylase 6B, anticorps kdm6b, anticorps KDM6B, anticorps kdm6bb, anticorps Kdm6b

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: Histone demethylase JMJD3, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, KIAA0346, Lysine demethylase 6B

ID gène: 23135, 9606

UniProt: O15054

Pathways: L'effet Warburg