ARF1 anticorps

N° du produit ABIN5557419

Cet anticorps Lapin Monoclonal détecte spécifiquement ARF1 dans WB et IF (cc). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour ARF1 anticorps (ABIN5557419)

Antigène: ARF1 (ADP-Ribosylation Factor 1 (ARF1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ARF1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 1D4

Détail du produit anti-ARF1 anticorps

Purification: Purified by Protein A.

Immunogène: Recombinant human ARF1 protein, full length.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Stock: -20 °C

Stockage commentaire: Store at -20°C

Date de péremption: 12 months

Détails sur ARF1

Antigène: ARF1 (ADP-Ribosylation Factor 1 (ARF1))

Autre désignation: ARF1

Sujet:

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Synonyms: ADP-ribosylation factor 1, ARF1

ID gène: 375

UniProt: P84077

Pathways: Transition Metal Ion Homeostasis, Inositol Metabolic Process