Recombinant CD40L (Ruplizumab Biosimilar) anticorps

N° du produit ABIN5564228

Cet anticorps Human Monoclonal détecte spécifiquement CD40L (Ruplizumab Biosimilar) dans FACS, WB et Func. Il présente une réactivité avec des échantillons de Humain et Chien.

Aperçu rapide pour Recombinant CD40L (Ruplizumab Biosimilar) anticorps (ABIN5564228)

Antigène: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Chien

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40L (Ruplizumab Biosimilar) est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)

Clone: Hu5c8

Détail du produit anti-CD40L (Ruplizumab Biosimilar) anticorps

Fonction: anti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)

Specificité: Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL. Cross-reacts with canine CD40L.

Réactivité croisée (Details): Cross-reacts with canine CD40L.

Attributs du produit: Recombinant Antibody. Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL. Cross-reacts with canine CD40L. Species cross-reactivity: Dog, Human. Clone: hu5c8. Isotype: Human IgG1kappa. Applications: FACS, FUNC, FUNC (Blocking), WB. Host: . Liquid. In PBS. CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.001EU/μg

Immunogène: Recombinant human CD40L.

Isotype: IgG1 kappa

Information d'application

Commentaires:

This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.

Date de péremption: 12 months

Détails sur CD40L (Ruplizumab Biosimilar)

Antigène: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Autre désignation: CD40L (Ruplizumab Biosimilar)

Classe de substances: Biosimilar

Sujet:

Alternate Names/Synonyms: CD40 Ligand, CD154, Tumor Necrosis Factor Ligand Superfamily Member 5,TNFSF5, Gp39, TRAP

Product Description: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

UniProt: P29965