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APOA1 anticorps

APOA1 Reactivité: Humain WB, ELISA, IHC, IP Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN5596807
  • Antigène Voir toutes APOA1 Anticorps
    APOA1 (Apolipoprotein A-I (APOA1))
    Reactivité
    • 119
    • 39
    • 23
    • 10
    • 10
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 91
    • 51
    • 17
    • 5
    • 3
    • 3
    • 2
    Chèvre
    Clonalité
    • 112
    • 58
    Polyclonal
    Conjugué
    • 86
    • 33
    • 15
    • 13
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp APOA1 est non-conjugé
    Application
    • 108
    • 81
    • 42
    • 21
    • 19
    • 15
    • 13
    • 13
    • 10
    • 8
    • 5
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    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Réactivité croisée (Details)
    Typically less than 1% cross-reactivity against other types of apoLipoprotein was detected by ELISA against purified standards. This antibody reacts with human apoLipoprotein A-I and has negligible cross-reactivity with Type A-II, B, C-I, C-II, C-III, E and J apoLipoproteins. Specific cross-reaction of anti-apoLipoprotein antibodies with antigens from other species has not been determined. Non-specific cross-reaction of anti-apoLipoprotein antibodies with other human serum proteins is negligible.
    Purification
    This product has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other apoLipoproteins and human serum proteins to remove any unwanted specificities.
    Immunogène

    Immunogen: apoLipoprotein Type A-I was isolated from human plasma by density gradient centrifugation followed by HPLC purification.

    Immunogen Type: Native Protein

    Isotype
    IgG
    Top Product
    Discover our top product APOA1 Anticorps primaire
  • Indications d'application

    Immunohistochemistry Dilution: 1:50 - 1:200

    Application Note: Anti-apoLipoprotein antibodies have been used for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for immunoprecipitation, immunohistochemistry and for western blotting for highly sensitive qualitative analysis.

    Western Blot Dilution: 1:1,000 - 1:2,000

    Immunoprecipitation Dilution: 1:100

    ELISA Dilution: 1:10,000 - 1:20,000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer

    Buffer: 0.125 M Sodium Borate, 0.075 M Sodium Chloride, 0.005 M EDTA, pH 8.0

    Stabilizer: None

    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store vial at 4° C prior to opening. This product is stable at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage mix with an equal volume of glycerol, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing.
    Date de péremption
    12 months
  • Jani, Orlicky, Karimpour-Fard, Epperson, Russell, Hunter, Martin: "Kidney proteome changes provide evidence for a dynamic metabolism and regional redistribution of plasma proteins during torpor-arousal cycles of hibernation." dans: Physiological genomics, Vol. 44, Issue 14, pp. 717-27, (2012) (PubMed).

    Otis, Sahoo, Drover, Yen, Carey: "Cholesterol and lipoprotein dynamics in a hibernating mammal." dans: PLoS ONE, Vol. 6, Issue 12, pp. e29111, (2012) (PubMed).

    Martin, Epperson, Rose, Kurtz, Ané, Carey: "Proteomic analysis of the winter-protected phenotype of hibernating ground squirrel intestine." dans: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 295, Issue 1, pp. R316-28, (2008) (PubMed).

  • Antigène
    APOA1 (Apolipoprotein A-I (APOA1))
    Autre désignation
    APOLIPOPROTEIN A-I (APOA1 Produits)
    Synonymes
    anticorps Alp-1, anticorps Apoa-1, anticorps Brp-14, anticorps Ltw-1, anticorps Lvtw-1, anticorps Sep-1, anticorps Sep-2, anticorps Sep2, anticorps apoA-I, anticorps apoa, anticorps apoa1, anticorps cb49, anticorps wu:fb33f01, anticorps zgc:103718, anticorps MGC64335, anticorps MGC89745, anticorps Apo-AI, anticorps ApoA-I, anticorps APOA1, anticorps LOC100136573, anticorps apoa-i, anticorps ApoAI, anticorps apolipoprotein A1, anticorps apolipoprotein A-I, anticorps apolipoprotein A-Ia, anticorps apolipoprotein A-I S homeolog, anticorps apolipoprotein A4, anticorps APOA1, anticorps Apoa1, anticorps apoa1a, anticorps apoa1.S, anticorps apoa1, anticorps LOC100136573, anticorps apoa-i, anticorps apoa4
    Sujet

    Synonyms: APOA1 antibody, APOA1/APOC3 fusion gene antibody, Apolipoprotein A I precursor antibody, Apolipoprotein AI antibody, Apolipoprotein of high density lipoprotein antibody

    Background: Anti Apolipoprotein A-I antibody recognizes the gene product of APOA1. Apolipoprotein promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids, an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease. This antibody is suitable for cardiovascular research.

    Gene Name: APOA1

    ID gène
    335
    UniProt
    P02647
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism
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