GBA anticorps (AA 146-235)

N° du produit ABIN561009

Cité dans 5 publications. Cet anticorps anti-GBA Monoclonal Souris (Clone 2E2) (ABIN561009) détecte spécifiquement GBA dans WB, ELISA, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GBA anticorps (AA 146-235) (ABIN561009)

Antigène: GBA (Glucosidase, Beta, Acid (GBA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GBA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2E2

Détail du produit anti-GBA anticorps

Épitope: AA 146-235

Fonction: Mouse monoclonal antibody raised against a partial recombinant GBA.

Séquence: SYFSEEGIGY NIIRVPMASC DFSIRTYTYA DTPDDFQLHN FSLPEEDTKL KIPLIHRALQ LAQRPVSLLA SPWTSPTWLK TNGAVNGKGS

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: GBA (NP_000148, 146 a.a. ~ 235 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-GBA (ABIN561009)

Murphy, Gysbers, Abbott, Tayebi, Kim, Sidransky, Cooper, Garner, Halliday: "Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease." dans: Brain : a journal of neurology, Vol. 137, Issue Pt 3, pp. 834-48, (2014) (PubMed).

Bendikov-Bar, Rapaport, Larisch, Horowitz: "Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS." dans: Orphanet journal of rare diseases, Vol. 9, pp. 86, (2014) (PubMed).

Bendikov-Bar, Horowitz: "Gaucher disease paradigm: from ERAD to comorbidity." dans: Human mutation, Vol. 33, Issue 10, pp. 1398-407, (2012) (PubMed).

Bendikov-Bar, Ron, Filocamo, Horowitz: "Characterization of the ERAD process of the L444P mutant glucocerebrosidase variant." dans: Blood cells, molecules & diseases, Vol. 46, Issue 1, pp. 4-10, (2011) (PubMed).

Campeau, Rafei, Boivin, Sun, Grabowski, Galipeau: "Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome." dans: Blood, Vol. 114, Issue 15, pp. 3181-90, (2009) (PubMed).

Détails sur GBA

Antigène: GBA (Glucosidase, Beta, Acid (GBA))

Autre désignation: GBA

Sujet: Full Gene Name: glucosidase, beta, acid (includes glucosylceramidase)
Synonyms: GBA1,GCB,GLUC

ID gène: 2629

NCBI Accession: NM_000157

Pathways: Cellular Glucan Metabolic Process