Adenosine A2a Receptor anticorps (AA 274-412)

N° du produit ABIN5611128

L’anticorps Souris Monoclonal anti-Adenosine A2a Receptor a été validé pour ELISA, FACS et ICC. Il convient pour détecter Adenosine A2a Receptor dans des échantillons de Humain.

Aperçu rapide pour Adenosine A2a Receptor anticorps (AA 274-412) (ABIN5611128)

Antigène: Adenosine A2a Receptor (ADORA2A)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Adenosine A2a Receptor est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 6A6G11

Détail du produit anti-Adenosine A2a Receptor anticorps

Épitope: AA 274-412

Fonction: ADORA2A Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100 - 1/500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur Adenosine A2a Receptor

Antigène: Adenosine A2a Receptor (ADORA2A)

Autre désignation: ADORA2A

Sujet: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Poids moléculaire: 44.7 kDa

ID gène: 135

UniProt: P29274

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints