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GRM8 anticorps (AA 440-583)

GRM8 Reactivité: Humain WB, ELISA, IHC, ICC, FACS, Neut Hôte: Souris Monoclonal 4C1C1 unconjugated
N° du produit ABIN5611162
  • Antigène Voir toutes GRM8 Anticorps
    GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
    Épitope
    • 12
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 440-583
    Reactivité
    • 36
    • 24
    • 15
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 2
    Souris
    Clonalité
    • 35
    • 1
    Monoclonal
    Conjugué
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GRM8 est non-conjugé
    Application
    • 23
    • 17
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human GRM8 (AA: extra 440-583) expressed in E. coli.
    Clone
    4C1C1
    Isotype
    IgG1
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Antigène
    GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
    Autre désignation
    GRM8 (GRM8 Produits)
    Synonymes
    anticorps mGluR8, anticorps GRM8, anticorps MGLUR8, anticorps GLUR8, anticorps GPRC1H, anticorps mGlu8, anticorps A230002O04, anticorps Gprc1h, anticorps Glur8, anticorps Mglur8, anticorps mGluR8b, anticorps mGlur, anticorps glutamate metabotropic receptor 8, anticorps metabotropic glutamate receptor 8, anticorps glutamate receptor, metabotropic 8, anticorps GRM8, anticorps MGLUR8, anticorps LOAG_14062, anticorps Grm8
    Sujet

    Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

    Aliases: GLUR8, mGlu8, GPRC1H, MGLUR8

    Poids moléculaire
    101.7 kDa
    ID gène
    2918
    HGNC
    2918
    Pathways
    cAMP Metabolic Process, Synaptic Membrane
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