MUTYH anticorps (AA 436-535)

N° du produit ABIN561883

Cet anticorps Souris Monoclonal détecte spécifiquement MUTYH dans WB, ELISA, IP et RNAi. Il présente une réactivité envers Humain et a été mentionné dans 7+ publications.

Aperçu rapide pour MUTYH anticorps (AA 436-535) (ABIN561883)

Antigène: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUTYH est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), RNA Interference (RNAi)

Clone: 4D10

Détail du produit anti-MUTYH anticorps

Épitope: AA 436-535

Fonction: Mouse monoclonal antibody raised against a partial recombinant MUTYH.

Séquence: KLTYQVYGLA LEGQTPVTTV PPGARWLTQE EFHTAAVSTA MKKVFRVYQG QQPGTCMGSK RSQVSSPCSR KKPRMGQQVL DNFFRSHIST DAHSLNSAAQ

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: MUTYH (AAH03178, 436 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-MUTYH (ABIN561883)

Komine, Shimodaira, Takao, Soeda, Zhang, Takahashi, Ishioka: "Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia Coli Strain." dans: Human mutation, Vol. 36, Issue 7, pp. 704-11, (2015) (PubMed).

Shinmura, Goto, Tao, Kato, Suzuki, Nakamura, Matsuda, Yin, Morita, Kono, Sugimura: "Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer." dans: Oxidative medicine and cellular longevity, Vol. 2014, pp. 617351, (2014) (PubMed).

Agustina, Hahm, Han, Tran, Chung, Park, Park, Han: "Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation." dans: BMC molecular biology, Vol. 15, pp. 17, (2014) (PubMed).

Raetz, Xie, Kundu, Brinkmeyer, Chang, David: "Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells." dans: Carcinogenesis, Vol. 33, Issue 11, pp. 2301-9, (2012) (PubMed).

Hahm, Chung, Agustina, Han, Yoon, Park, Kang, Park, Na, Han: "Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells." dans: Oncology letters, Vol. 4, Issue 6, pp. 1203-1208, (2012) (PubMed).

Suzuki, Harashima, Kamiya: "Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine." dans: DNA repair, Vol. 9, Issue 5, pp. 542-50, (2010) (PubMed).

van der Post, Kets, Ligtenberg, van Krieken, Hoogerbrugge: "Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis." dans: Virchows Archiv : an international journal of pathology, Vol. 454, Issue 1, pp. 25-9, (2008) (PubMed).

Détails sur MUTYH

Antigène: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Autre désignation: MUTYH

Sujet: Full Gene Name: mutY homolog (E. coli)
Synonyms: MGC4416,MYH

ID gène: 4595

Pathways: Réparation de l'ADN