YAP1 anticorps (AA 53-161)

N° du produit ABIN564526

Cet anticorps Souris Monoclonal détecte spécifiquement YAP1 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 17+ publications.

Aperçu rapide pour YAP1 anticorps (AA 53-161) (ABIN564526)

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp YAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2F12

Détail du produit anti-YAP1 anticorps

Épitope: AA 53-161

Fonction: Mouse monoclonal antibody raised against a partial recombinant YAP1.

Séquence: QIVHVRGDSE TDLEALFNAV MNPKTANVPQ TVPMRLRKLP DSFFKPPEPK SHSRQASTDA GTAGALTPQH VRAHSSPASL QLGAVSPGTL TPTGVVSGPA ATPTAQHLR

Réactivité croisée: Humain, Souris

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: YAP1 (NP_006097, 53 a.a. ~ 161 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-YAP1 (ABIN564526)

Toyooka, Oka, Fujimori: "Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes." dans: Developmental biology, Vol. 411, Issue 1, pp. 50-60, (2016) (PubMed).

Abbassi, Malki, Cockburn, Macaulay, Robert, Rossant, Clarke: "Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis." dans: Biology of reproduction, Vol. 94, Issue 5, pp. 102, (2016) (PubMed).

Junemann, Birgin, Erdmann, Schröder, Just, Gerhard, Pich: "Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells." dans: Proteomics. Clinical applications, Vol. 11, Issue 3-4, (2016) (PubMed).

Yang, Zhang, Chen, Chen, Dong: "Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1." dans: The Journal of biological chemistry, Vol. 290, Issue 10, pp. 6191-202, (2015) (PubMed).

Shao, Zhai, Del Re, Sciarretta, Yabuta, Nojima, Lim, Pan, Sadoshima: "A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response." dans: Nature communications, Vol. 5, pp. 3315, (2014) (PubMed).

Adler, Heller, Bringman, Ranahan, Cocklin, Goebl, Oh, Lim, Ingham, Wells: "Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth." dans: The Journal of biological chemistry, Vol. 288, Issue 21, pp. 15181-93, (2013) (PubMed).

Das, Tanigawa, Karner, Xin, Lum, Chen, Olson, Perantoni, Carroll: "Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation." dans: Nature cell biology, Vol. 15, Issue 9, pp. 1035-44, (2013) (PubMed).

Yang, Zhang, Liu, Chong, Ding, Chen, Dong: "CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation." dans: Cancer research, Vol. 73, Issue 22, pp. 6722-33, (2013) (PubMed).

Adler, Johnson, Heller, Bringman, Ranahan, Conwell, Sun, Hudmon, Wells: "Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 43, pp. 17368-73, (2013) (PubMed).

Skouloudaki, Walz: "YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation." dans: PLoS ONE, Vol. 7, Issue 4, pp. e35735, (2012) (PubMed).

Hirate, Cockburn, Rossant, Sasaki: "Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 50, pp. E3389-90; author reply E3391-2, (2012) (PubMed).

Murakami, Mizuno, Taniguchi, Fujii, Ishiguro, Fukui, Akatsuka, Horio, Hida, Kondo, Toyokuni, Osada, Sekido: "LATS2 is a tumor suppressor gene of malignant mesothelioma." dans: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).

Leivonen, Rokka, Ostling, Kohonen, Corthals, Kallioniemi, Perälä: "Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact." dans: Molecular & cellular proteomics : MCP, Vol. 10, Issue 7, pp. M110.005322, (2011) (PubMed).

Sekido: "Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation." dans: Pathology international, Vol. 61, Issue 6, pp. 331-44, (2011) (PubMed).

Wada, Itoga, Okano, Yonemura, Sasaki: "Hippo pathway regulation by cell morphology and stress fibers." dans: Development (Cambridge, England), Vol. 138, Issue 18, pp. 3907-14, (2011) (PubMed).

Tomlinson, Gudmundsdottir, Luong, Leung, Knebel, Basu: "JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis." dans: Cell death & disease, Vol. 1, pp. e29, (2011) (PubMed).

Lau, Murray, Houshmandi, Xu, Gutmann, Yu: "Merlin is a potent inhibitor of glioma growth." dans: Cancer research, Vol. 68, Issue 14, pp. 5733-42, (2008) (PubMed).

Détails sur YAP1

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Autre désignation: YAP1

Sujet: Full Gene Name: Yes-associated protein 1, 65 kDa
Synonyms: YAP,YAP2,YAP65,YKI

ID gène: 10413

NCBI Accession: NM_006106

Pathways: Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha