Emerin anticorps (AA 1-48)

N° du produit ABIN5647115

Détail du produit anti-Emerin anticorps

Antigène: Emerin (EMD)

Épitope: AA 1-48

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Emerin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: Amino acids 1-48 (MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL-human) were used as the immunogen for the Emerin antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Emerin antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Emerin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Emerin

Antigène: Emerin (EMD)

Autre désignation: Emerin (EMD Produits)

Synonymes: anticorps fj58f01, anticorps wu:fj58f01, anticorps EMD, anticorps Bocks, anticorps Bocksbeutel, anticorps CG9424, anticorps Dmel\\CG9424, anticorps emerin, anticorps emd, anticorps xemd1, anticorps xemerin2, anticorps xemd2, anticorps xemerin1, anticorps EDMD, anticorps LEMD5, anticorps STA, anticorps AW550900, anticorps Sta, anticorps emerin, anticorps emerin (Emery-Dreifuss muscular dystrophy), anticorps bocksbeutel, anticorps emerin L homeolog, anticorps emerin S homeolog, anticorps EMD, anticorps emd, anticorps bocks, anticorps emd.L, anticorps emd.S, anticorps Emd

Sujet: Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene. And this gene is mapped to Xq28. Emerin is a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Emery-Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene. Emerin appears to be involved in mechanotransduction, as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli. In cardiac muscle, emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs, and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta.

UniProt: P50402