TDP1 anticorps (AA 1-608)

N° du produit ABIN565920

Cet anticorps anti-TDP1 est un anticorps Souris Polyclonal détectant TDP1 dans WB et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour TDP1 anticorps (AA 1-608) (ABIN565920)

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Polyclonal

Conjugué: Cet anticorp TDP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TDP1 anticorps

Épitope: AA 1-608

Fonction: Mouse polyclonal antibody raised against a full-length recombinant TDP1.

Séquence: MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET NVYLIGSTPG RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS VGSLGADESK WLCSEFKESM LTLGKESKTP GKSSVPLYLI YPSVENVRTS LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW SAETSGRSNA MPHIKTYMRP SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG VLFLPSAFGL DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT HGNMWVPS

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: TDP1 (AAH15474.1, 1 a.a. ~ 608 a.a) full-length recombinant protein with GST tag.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 % glycerol

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-TDP1 (ABIN565920)

Das, Huang, Murai, Rehman, Amé, Sengupta, Das, Majumdar, Zhang, Biard, Majumder, Schreiber, Pommier: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." dans: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).

Katyal, Lee, Nitiss, Downing, Li, Shimada, Zhao, Russell, Petrini, Nitiss, McKinnon: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." dans: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).

Hawkins, Subler, Akopiants, Wiley, Taylor, Rice, Windle, Valerie, Povirk: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." dans: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).

Das, Antony, Gupta, Dexheimer, Redon, Garfield, Shiloh, Pommier: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." dans: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).

Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." dans: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).

Détails sur TDP1

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Autre désignation: TDP1

Sujet: Full Gene Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: FLJ11090,MGC104252

ID gène: 55775