TDP1 anticorps (AA 1-608)

N° du produit ABIN565920

Détail du produit anti-TDP1 anticorps

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Épitope: AA 1-608

Reactivité: Humain

Hôte: Souris

Clonalité: Polyclonal

Conjugué: Cet anticorp TDP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Mouse polyclonal antibody raised against a full-length recombinant TDP1.

Séquence: MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET NVYLIGSTPG RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS VGSLGADESK WLCSEFKESM LTLGKESKTP GKSSVPLYLI YPSVENVRTS LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW SAETSGRSNA MPHIKTYMRP SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG VLFLPSAFGL DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT HGNMWVPS

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: TDP1 (AAH15474.1, 1 a.a. ~ 608 a.a) full-length recombinant protein with GST tag.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 % glycerol

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-TDP1 (ABIN565920)

Das, Huang, Murai, Rehman, Amé, Sengupta, Das, Majumdar, Zhang, Biard, Majumder, Schreiber, Pommier: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." dans: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).

Katyal, Lee, Nitiss, Downing, Li, Shimada, Zhao, Russell, Petrini, Nitiss, McKinnon: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." dans: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).

Hawkins, Subler, Akopiants, Wiley, Taylor, Rice, Windle, Valerie, Povirk: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." dans: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).

Das, Antony, Gupta, Dexheimer, Redon, Garfield, Shiloh, Pommier: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." dans: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).

Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." dans: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).

Détails sur TDP1

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Autre désignation: TDP1 (TDP1 Produits)

Synonymes: anticorps 2810481F14Rik, anticorps 4921509N21Rik, anticorps AI838772, anticorps AW493413, anticorps E430034L06Rik, anticorps MLZ-501, anticorps SCAN1, anticorps tdp1, anticorps MGC83708, anticorps TDP1, anticorps F8M21.60, anticorps F8M21_60, anticorps tyrosyl-DNA phosphodiesterase 1, anticorps tyrosyl-DNA phosphodiesterase 1, anticorps tyrosyl-DNA Phosphodiesterase (Tdp1), anticorps tyrosyl-DNA phosphodiesterase 1 L homeolog, anticorps tyrosyl-DNA phosphodiesterase-like protein, anticorps TDP1, anticorps Tc00.1047053511191.10, anticorps Tdp1, anticorps tdp1.L, anticorps tdp1, anticorps PTRG_11198, anticorps MCYG_02121, anticorps MGYG_03035

Sujet: Full Gene Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: FLJ11090,MGC104252

ID gène: 55775