Recombinant CD4 (Clenoliximab Biosimilar) anticorps

N° du produit ABIN5668248

L’anticorps Lapin Chimeric anti- a été validé pour BR, ELISA, FACS, IHC et SPR. Il convient pour détecter dans des échantillons de Humain et Chimpanzé.

Aperçu rapide pour Recombinant CD4 (Clenoliximab Biosimilar) anticorps (ABIN5668248)

Antigène: CD4 (Clenoliximab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Chimpanzé

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Inconjugué

Application: Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Surface Plasmon Resonance (SPR)

Clone: CE9-1

Détail du produit

Fonction: Anti-CD4 [CE9.1 (Clenoliximab)], Rabbit IgG, lambda

Specificité: The antibody binds to human CD4 with a Kd of 1.0 nM and an ED50 of 0.2 μg/mL.

Réactivité croisée: Chimpanzé

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG4 (primatized)

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: Domain 1 of human CD4.

Isotype: IgG lambda

Information d'application

Indications d'application: The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 Molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 (primatized) format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: CD4 (Clenoliximab Biosimilar)

Classe de substances: Biosimilar

Sujet: P55, T cell surface antign T4/Leu-3.

UniProt: P01730