Recombinant IL-6R (Tocilizumab Biosimilar) anticorps
Reactivité: Humain
ELISA, InhA
Hôte: Lapin
Monoclonal
RhPM-1
unconjugated
Recombinant Antibody
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- Antigène Tous les produits IL-6R (Tocilizumab Biosimilar)
- IL-6R (Tocilizumab Biosimilar)
- Type d'anticorp
- Recombinant Antibody
- Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IL-6R (Tocilizumab Biosimilar) est non-conjugé
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Application
- ELISA, Inhibition Assay (InhA)
- Specificité
- Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
- Attributs du produit
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Purification
- Purified antibody.
- Pureté
- > 98 % as determined by SDS-PAGE
- niveau d'endotoxine
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogène
- This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
- Clone
- RhPM-1
- Isotype
- IgG kappa
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- Indications d'application
- Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
- Commentaires
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % Proclin 300.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Antigène
- IL-6R (Tocilizumab Biosimilar)
- Abstract
- IL-6R (Tocilizumab Biosimilar) Produits
- Synonymes
- anticorps CD126, anticorps IL-6R-1, anticorps IL-6RA, anticorps IL6Q, anticorps IL6RA, anticorps IL6RQ, anticorps gp80, anticorps interleukin 6 receptor, anticorps IL6R
- Classe de substances
- Biosimilar
- Sujet
- IL6R, MRA, atlizumab
- UniProt
- A0N0L5
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