EIF3B anticorps (N-Term)

N° du produit ABIN5672523

Cet anticorps anti-EIF3B est un anticorps Polyclonal produit chez le Lapin, détectant EIF3B dans WB. Convient pour Humain.

Aperçu rapide pour EIF3B anticorps (N-Term) (ABIN5672523)

Antigène: EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EIF3B anticorps

Épitope: N-Term

Séquence: AAEELPGSHA EPPVPAQGEA PGEQARDERS DSRAQAVSED AGGNEGRAAE

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human EIF3B

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EIF3B

Antigène: EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))

Autre désignation: EIF3B

Sujet: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.

Alias Symbols: PRT1, EIF3S9, EIF3-ETA, EIF3-P110, EIF3-P116

Protein Size: 873

ID gène: 8662

NCBI Accession: NM_001037283, NP_001032360

Pathways: Ribonucleoprotein Complex Subunit Organization