FIP1L1 anticorps (N-Term)

N° du produit ABIN5673070

L’anticorps Lapin Polyclonal anti-FIP1L1 a été validé pour WB. Il convient pour détecter FIP1L1 dans des échantillons de Humain.

Aperçu rapide pour FIP1L1 anticorps (N-Term) (ABIN5673070)

Antigène: FIP1L1 (FIP1 Like 1 (FIP1L1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FIP1L1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FIP1L1 anticorps

Épitope: N-Term

Séquence: GIEDETAENG VPKPKVTETE DDSDSDSDDD EDDVHVTIGD IKTGAPQYGS

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of Human FIP1L1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur FIP1L1

Antigène: FIP1L1 (FIP1 Like 1 (FIP1L1))

Autre désignation: FIP1L1

Sujet: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alias Symbols: Rhe, FIP1, hFip1

Protein Size: 594

ID gène: 81608

NCBI Accession: NM_001134937, NP_001128409

UniProt: Q6UN15