NGEF anticorps (C-Term)

N° du produit ABIN5673216

Cet anticorps Lapin Polyclonal détecte spécifiquement NGEF dans WB. Il présente une réactivité envers Souris.

Aperçu rapide pour NGEF anticorps (C-Term) (ABIN5673216)

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGEF est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NGEF anticorps

Épitope: C-Term

Séquence: GWFPSSMTEE ILNPKIRSQN LKECFRVHKM EDPQRSQNKD RRKLGSRNRQ

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of mouse NGEF

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NGEF

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Autre désignation: NGEF

Sujet: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

Alias Symbols: Tims2, ephexin

Protein Size: 620

ID gène: 53972

NCBI Accession: NM_001111314, NP_001104784

Pathways: Neurotrophin Signaling Pathway