KAT5 anticorps (pSer86) (HRP)

N° du produit ABIN5675418

Cet anticorps Lapin Polyclonal détecte spécifiquement KAT5 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour KAT5 anticorps (pSer86) (HRP) (ABIN5675418)

Antigène: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KAT5 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-KAT5 anticorps (HRP)

Épitope: pSer86

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthesised phosphopeptide derived from human KAT5 around the phosphorylation site of Ser86

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur KAT5

Antigène: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Autre désignation: KAT5

Sujet:

Synonyms: Histone acetyltransferase KAT5, KAT5, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5, HTATIP, TIP60

Background: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

ID gène: 10524

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway