POLD1 anticorps

N° du produit ABIN567776

L’anticorps anti-POLD1 Monoclonal Rat est utilisé pour la détection de POLD1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour POLD1 anticorps (ABIN567776)

Antigène: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Reactivité: Humain, Souris, Rat

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp POLD1 est non-conjugé

Application: Western Blotting (WB)

Clone: 5G1

Détail du produit anti-POLD1 anticorps

Specificité: This antibody reacts with DNA polymerase delta p125 catalytic subunit (125 kDa) by Western blotting.

Purification: Protein-G Agarose Chromatography of hybridoma supernatant.

Immunogène: Recombinant full length His-Human p125.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur POLD1

Antigène: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Autre désignation: POLD1

Sujet: In eukaryotic cells, 3 types of DNA polymerases (pol), pol alpha, pol delta and pol epsilon function in accurate and efficient DNA replication. Pol delta is a heteromultimeric enzyme composed of a 125 kDa major catalytic subunit and three smaller accessory subunits. Pol delta requires a number of accessory molecules to exert its full activity. Proliferating cell nuclear antigen (PCNA) forms a doughnut-shaped trimer with a 35 Ä hole and works as the sliding clamp and replication factor C acts as the clamp loader to improve Pol delta processivity. Pol delta is also involved in nucleotide excision repair of DNA.Synonyms: DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125

ID gène: 5424

NCBI Accession: NP_002682

UniProt: P28340

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Chromatin Binding, Synthesis of DNA