S1PR2 anticorps (Internal Region)

N° du produit ABIN568703

Il existe 1 publication pour ce produit. L’anticorps anti-S1PR2 Polyclonal Chèvre est utilisé pour la détection de S1PR2 dans des échantillons de Humain, Souris, Rat et Chien. Il a été validé pour WB et EIA.

Aperçu rapide pour S1PR2 anticorps (Internal Region) (ABIN568703)

Antigène: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-S1PR2 anticorps

Épitope: Internal Region

Séquence: C-NYTKETLETQ

Specificité: Recognizes EDG-5 / S1P2.

Réactivité croisée (Details): Species reactivity (expected):Dog.
Species reactivity (tested):Human, Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_004221.3. Genename: S1PR2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-S1PR2 (ABIN568703)

Song, Hou, Chen, Cheng, Lei, Cui, Sun, Wang, Fang: "Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome." dans: Anesthesiology, Vol. 129, Issue 2, pp. 311-320, (2019) (PubMed).

Détails sur S1PR2

Antigène: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Autre désignation: EDG-5 / S1P2

Sujet: The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: AGR16, EDG5, Endothelial differentiation G-protein coupled receptor 5, Gpcr13, H218, LPB2, S1P receptor 2, S1PR2, Sphingosine 1-phosphate receptor 2

ID gène: 9294

NCBI Accession: NP_004221

UniProt: O95136

Pathways: Synaptic Membrane