Tryptophan Hydroxylase 1 anticorps (pSer19)

N° du produit ABIN5688890

Cet anticorps anti-Tryptophan Hydroxylase 1 est un anticorps Lapin Polyclonal détectant Tryptophan Hydroxylase 1 dans WB. Adapté pour Souris, Rat, Boeuf (Vache) et Xenopus laevis.

Aperçu rapide pour Tryptophan Hydroxylase 1 anticorps (pSer19) (ABIN5688890)

Antigène: Tryptophan Hydroxylase 1 (TPH1)

Reactivité: Souris, Rat, Boeuf (Vache), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tryptophan Hydroxylase 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Tryptophan Hydroxylase 1 anticorps

Épitope: pSer19

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser19 of rat tryptophan hydroxylase 2 (TPH2).

Information d'application

Indications d'application: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, mouse and zebra fish based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: Tryptophan Hydroxylase antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Détails sur Tryptophan Hydroxylase 1

Antigène: Tryptophan Hydroxylase 1 (TPH1)

Autre désignation: Tryptophan Hydroxylase

Sujet: Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II) (Jiang et al., 2000, Johansen et al., 1996). CaM K II phosphorylates Ser19 which lies within the regulatory domain of TPH2 (McKinney et

Poids moléculaire: 55 kDa

ID gène: 317675

UniProt: Q8CGU9

Pathways: Feeding Behaviour