AQP2 anticorps (pSer261)

N° du produit ABIN5688893

Cet anticorps anti-AQP2 est un anticorps Lapin Polyclonal détectant AQP2 dans WB et IHC. Adapté pour Humain, Rat, Souris, Boeuf (Vache), Chien et Poulet. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour AQP2 anticorps (pSer261) (ABIN5688893)

Antigène: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AQP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-AQP2 anticorps

Épitope: pSer261

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser261 of rat aquaporin 2.

Information d'application

Indications d'application: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with canine, bovine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: Aquaporin 2 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Références pour anticorps anti-AQP2 (ABIN5688893)

Sugito, Etriwati, Akmal, Rahmi, Delima, Muchlisin, Hasan: "Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure." dans: TheScientificWorldJournal, Vol. 2021, pp. 8711286, (2022) (PubMed).

Détails sur AQP2

Antigène: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Autre désignation: Aquaporin 2

Sujet: Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al., 2007).

Poids moléculaire: 29/37 kDa

ID gène: 25386

UniProt: P34080

Pathways: Response to Water Deprivation