AQP2 anticorps (pSer261)

N° du produit ABIN5688893

Cité dans 1 publication. Cet anticorps anti-AQP2 Polyclonal Lapin (ABIN5688893) détecte spécifiquement AQP2 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Chien, Boeuf (Vache) et Poulet.

Aperçu rapide pour AQP2 anticorps (pSer261) (ABIN5688893)

Antigène: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AQP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-AQP2 anticorps

Épitope: pSer261

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser261 of rat aquaporin 2.

Information d'application

Indications d'application: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with canine, bovine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: Aquaporin 2 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Références pour anticorps anti-AQP2 (ABIN5688893)

Sugito, Etriwati, Akmal, Rahmi, Delima, Muchlisin, Hasan: "Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure." dans: TheScientificWorldJournal, Vol. 2021, pp. 8711286, (2022) (PubMed).

Détails sur AQP2

Antigène: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Autre désignation: Aquaporin 2

Sujet: Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al., 2007).

Poids moléculaire: 29/37 kDa

ID gène: 25386

UniProt: P34080

Pathways: Response to Water Deprivation