HDAC3 anticorps (AA 420-424)

N° du produit ABIN5689286

Cet anticorps anti-HDAC3 Polyclonal Lapin (ABIN5689286) détecte spécifiquement HDAC3 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HDAC3 anticorps (AA 420-424) (ABIN5689286)

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HDAC3 anticorps

Épitope: AA 420-424

Specificité: This antibody detects endogenous level of total HDAC3 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: HDAC3 antibody   was raised against a peptide sequence around aa.420~424 (N-D-K-E-S) derived from Human HDAC3.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur HDAC3

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Autre désignation: HDAC3 

Sujet: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

Poids moléculaire: 49 kDa

ID gène: 8841

NCBI Accession: NP_003874

UniProt: O15379

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development