SMC1A anticorps (AA 955-959)

N° du produit ABIN5689614

Cet anticorps Lapin Polyclonal détecte spécifiquement SMC1A dans WB et IHC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour SMC1A anticorps (AA 955-959) (ABIN5689614)

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SMC1A anticorps

Épitope: AA 955-959

Specificité: This antibody detects endogenous level of total SMC1 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: SMC1 (Ab-957) antibody was raised against a peptide sequence around aa. 955~959 (G-S-S-Q-G) derived from Human SMC1.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1

Sujet: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Poids moléculaire: 145 kDa

ID gène: 8243

NCBI Accession: NP_006297

UniProt: Q14683

Pathways: Stem Cell Maintenance