KREMEN2 anticorps (AA 390-440)

N° du produit ABIN5690035

L’anticorps anti-KREMEN2 Polyclonal produit chez le Lapin a été validé pour WB, ELISA et ICC. Il convient pour la détection de KREMEN2 dans des échantillons provenant de Humain et Souris. }

Aperçu rapide pour KREMEN2 anticorps (AA 390-440) (ABIN5690035)

Antigène: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KREMEN2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-KREMEN2 anticorps

Épitope: AA 390-440

Specificité: Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

Purification: KREMEN2 Antibody is affinity chromatography purified via peptide column.

Immunogène: KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .

The immunogen is located within amino acids 390 - 440 of KREMEN2.

Isotype: IgG

Information d'application

Indications d'application: KREMEN2 Antibody can be used for detection of KREMEN2 by Western blot starting at 1 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur KREMEN2

Antigène: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Autre désignation: KREMEN2

Sujet: KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

Poids moléculaire: Predicted: 51 kDa

Observed: 54 kDa

ID gène: 79412

NCBI Accession: NP_757384

UniProt: Q8NCW0

Pathways: Signalisation WNT