PINK1 anticorps (AA 120-170)

N° du produit ABIN5690101

L’anticorps Lapin Polyclonal anti-PINK1 a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter PINK1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PINK1 anticorps (AA 120-170) (ABIN5690101)

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PINK1 anticorps

Épitope: AA 120-170

Specificité: PINK1 antibody is human, mouse and rat reactive. At least two isoforms are known to exist, this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1.

Purification: PINK1 antibody is affinity chromatography purified via peptide column.

Immunogène: PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1.

The immunogen is located within amino acids 120 - 170 of PINK1.

Isotype: IgG

Information d'application

Indications d'application: PINK1 antibody can be used for detection of PINK1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PINK1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: PINK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: PINK1

Sujet: The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).

Poids moléculaire: Predicted: 55 kDa

Observed: 53 kDa

ID gène: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagy