SMURF1 anticorps (AA 180-230)

N° du produit ABIN5690258

Cet anticorps anti-SMURF1 Polyclonal Lapin (ABIN5690258) détecte spécifiquement SMURF1 dans WB, ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SMURF1 anticorps (AA 180-230) (ABIN5690258)

Antigène: SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMURF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SMURF1 anticorps

Épitope: AA 180-230

Specificité: SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.

Purification: SMURF1 antibody is affinity chromatography purified via peptide column.

Immunogène: SMURF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human SMURF1.

The immunogen is located within amino acids 180 - 230 of SMURF1.

Isotype: IgG

Information d'application

Indications d'application: SMURF1 body can be used for detection of SMURF1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SMURF1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: SMURF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur SMURF1

Antigène: SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))

Autre désignation: SMURF1

Sujet: SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2). SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3). SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4).

Poids moléculaire: Predicted: 80, 83 kDa

Observed: 78 kDa

ID gène: 57154

NCBI Accession: NP_065162

UniProt: Q9HCE7

Pathways: Regulation of Cell Size