TET2 anticorps (AA 1550-1600)

N° du produit ABIN5690284

L’anticorps Lapin Polyclonal anti-TET2 a été validé pour WB et ELISA. Il convient pour détecter TET2 dans des échantillons de Humain et Souris.

Aperçu rapide pour TET2 anticorps (AA 1550-1600) (ABIN5690284)

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TET2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TET2 anticorps

Épitope: AA 1550-1600

Specificité: TET2 antibody is human and mouse reactive. At least two isoforms of TET2 are known to exist, this antibody will detect the larger isoforms. This antibody is predicted to not cross-react with TET1 and TET3.

Purification: TET2 antibody is affinity chromatography purified via peptide column.

Immunogène: TET2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET2.

The immunogen is located within amino acids 1550 - 1600 of TET2.

Isotype: IgG

Information d'application

Indications d'application: TET2 antibody can be used for detection of TET2 by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TET2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur TET2

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Autre désignation: TET2

Sujet: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14 % of patients with JAK2V617F-positive myeloproliferative neoplasms (1), and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia (2). Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

Poids moléculaire: Predicted: 220 kDa

Observed: 220 kDa

ID gène: 54790

NCBI Accession: NP_001120680

UniProt: Q6N021

Pathways: L'effet Warburg