UVRAG anticorps (AA 490-540)

N° du produit ABIN5690316

Cet anticorps Lapin Polyclonal détecte spécifiquement UVRAG dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour UVRAG anticorps (AA 490-540) (ABIN5690316)

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UVRAG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-UVRAG anticorps

Épitope: AA 490-540

Specificité: UVRAG antibody is human and mouse reactive.

Purification: UVRAG antibody is affinity chromatography purified via peptide column.

Immunogène: UVRAG antibody was raised against an 18 amino acid peptide near the carboxy terminus of human UVRAG.

The immunogen is located within amino acids 490 - 540 of UVRAG.

Isotype: IgG

Information d'application

Indications d'application: UVRAG antibody can be used for detection of UVRAG by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: UVRAG antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: UVRAG antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur UVRAG

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Autre désignation: UVRAG

Sujet: The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1). UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2). UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5).

Poids moléculaire: Predicted: 77 kDa

Observed: 75 kDa

ID gène: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5