GPX8 anticorps (AA 38-209)

N° du produit ABIN5690344

L’anticorps Lapin Polyclonal anti-GPX8 a été validé pour WB et ICC. Il convient pour détecter GPX8 dans des échantillons de Humain.

Aperçu rapide pour GPX8 anticorps (AA 38-209) (ABIN5690344)

Antigène: GPX8 (Glutathione Peroxidase 8 (GPX8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPX8 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Détail du produit anti-GPX8 anticorps

Épitope: AA 38-209

Specificité: Recognizes human GPx8.

Immunogène: Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.

Information d'application

Indications d'application: Western Blot: (1:1,000). ICC: (1:200).

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for at least 1 year after receipt when stored at -20°C.

Détails sur GPX8

Antigène: GPX8 (Glutathione Peroxidase 8 (GPX8))

Autre désignation: GPx8

Sujet: GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24  kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.

ID gène: 493869

UniProt: Q8TED1

Pathways: Thyroid Hormone Synthesis