LTB anticorps (AA 31-221)

N° du produit ABIN5690617

L’anticorps anti-LTB Monoclonal Rat est utilisé pour la détection de LTB dans des échantillons de Souris. Il a été validé pour Func.

Aperçu rapide pour LTB anticorps (AA 31-221) (ABIN5690617)

Antigène: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp LTB est non-conjugé

Application: Functional Studies (Func)

Clone: 3C8

Détail du produit anti-LTB anticorps

Épitope: AA 31-221

Specificité: Recognizes mouse LTbetaR.

Pureté: > 95% (SDS-PAGE)

Immunogène: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Isotype: IgG1 kappa

Information d'application

Indications d'application: Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for at least 1 year after receipt when stored at -20°C.

Détails sur LTB

Antigène: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Autre désignation: LTbeta

Sujet: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

ID gène: 17000

UniProt: P50284

Pathways: Signalisation NF-kappaB