Cathepsin D anticorps (AA 161-358)

N° du produit ABIN5692809

Détail du produit anti-Cathepsin D anticorps

Antigène: Cathepsin D (CTSD)

Épitope: AA 161-358

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin D est non-conjugé

Application: Western Blotting (WB), ELISA

Marque: Picoband™

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Cathepsin D detection. Tested with WB, Direct ELISA in Mouse,Rat.

Immunogène: E. coli-derived mouse Cathepsin D recombinant protein (Position: K161-Q358).

Information d'application

Indications d'application:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot,0.1-0.5 μg/mL
Direct ELISA,0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Cathepsin D (ABIN5692809)

Zheng, Li, Wang, Wang, Liao, Hu, Fan, Kang, Zeng, Wu, Wu, Zhang, Wang, He et al.: "Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage ..." dans: Autophagy, Vol. 12, Issue 9, pp. 1593-613, (2017) (PubMed).

Détails sur Cathepsin D

Antigène: Cathepsin D (CTSD)

Autre désignation: Ctsd (CTSD Produits)

Synonymes: anticorps catD, anticorps fb93e11, anticorps fj17b09, anticorps wu:fb93e11, anticorps wu:fj17b09, anticorps LOC398557, anticorps Cathd, anticorps CatD, anticorps LOC100136761, anticorps CTSD, anticorps DKFZp469J0315, anticorps DDBDRAFT_0205785, anticorps DDBDRAFT_0215012, anticorps DDB_0205785, anticorps DDB_0215012, anticorps CLN10, anticorps CPSD, anticorps CD, anticorps cathepsin D, anticorps cathepsin D S homeolog, anticorps lysosomal aspartic protease, anticorps cathepsin D-like, anticorps ctsd, anticorps LOC398557, anticorps ctsd.S, anticorps CatD, anticorps LOC5567565, anticorps LOC100136761, anticorps CTSD, anticorps Cathd, anticorps ctsD, anticorps catd, anticorps Ctsd, anticorps LOC443060

Sujet:

Synonyms: Cathepsin D, Ctsd

Background: Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.

UniProt: P18242

Pathways: Peptide Hormone Metabolism