VCAM1 anticorps (AA 25-270)

N° du produit ABIN5692810

Il existe 7+ publications pour ce produit. L’anticorps anti-VCAM1 Polyclonal Lapin est utilisé pour la détection de VCAM1 dans des échantillons de Humain. Il a été validé pour IHC et ELISA.

Aperçu rapide pour VCAM1 anticorps (AA 25-270) (ABIN5692810)

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VCAM1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-VCAM1 anticorps

Épitope: AA 25-270

Fonction: Anti-VCAM1 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-VCAM1 Antibody (ABIN5692810). Tested in ELISA, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human VCAM1 recombinant protein (Position: F25-L270).

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA (Cap), 1-5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-VCAM1 (ABIN5692810)

Ma, Pan, Ren, Guo, Guo, Wei, Zheng, Chen: "15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell." dans: Lipids in health and disease, Vol. 16, Issue 1, pp. 137, (2018) (PubMed).

Wang, Qing, Liu, Liu, Qiao, Cui, He, Zhao, Liu, Yan, Wang, Liang, Guo, Shen, Hou, Chen: "Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling." dans: Stem cell research & therapy, Vol. 8, Issue 1, pp. 188, (2018) (PubMed).

Hoffman, Adeli: "LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis." dans: EBioMedicine, Vol. 28, pp. 17-18, (2018) (PubMed).

Tian, Tao, Zhao, Tai, Liu, Liu: "Isolation and morphological characterization of ovine amniotic fluid mesenchymal stem cells." dans: Experimental animals, Vol. 65, Issue 2, pp. 125-34, (2017) (PubMed).

Ma, Pan, Chen, Guo, Zhao, Zheng, Chen: "Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion." dans: Bioscience reports, Vol. 37, Issue 2, (2017) (PubMed).

Chen, Zhang, Chen, Liu, Wang, Zhou, Qiu, Zhang, Teng, Mao, Liu, Wei, Li: "Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis." dans: Annals of dermatology, Vol. 27, Issue 2, pp. 121-7, (2015) (PubMed).

Yu, Ge, Summers, Li, Liu, Ma, Kaminski, Zhuang: "TSP-1 secreted by bone marrow stromal cells contributes to retinal ganglion cell neurite outgrowth and survival." dans: PLoS ONE, Vol. 3, Issue 6, pp. e2470, (2008) (PubMed).

Détails sur VCAM1

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Autre désignation: VCAM1

Sujet:

Synonyms: Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1

Tissue Specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Background: CD106 (cluster of differentiation 106) also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. This gene is mapped to chromosome 1 by Southern analysis of somatic cell hybrids. VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated.

ID gène: 7412

UniProt: P19320

Pathways: Carbohydrate Homeostasis