MAX anticorps (AA 30-106)

N° du produit ABIN5692891

Détail du produit anti-MAX anticorps

Antigène: MAX (MYC Associated Factor X (MAX))

Épitope: AA 30-106

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAX est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Marque: Picoband™

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for MAX detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.

Immunogène: E. coli-derived human MAX recombinant protein (Position: A30-R106).

Information d'application

Indications d'application:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Application Details: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Détails sur MAX

Antigène: MAX (MYC Associated Factor X (MAX))

Autre désignation: MAX (MAX Produits)

Synonymes: anticorps CG9648, anticorps Dmel\\CG9648, anticorps MAX, anticorps bHLHd9, anticorps dMax, anticorps dmax, anticorps max, anticorps bhlhd4, anticorps bhlhd5, anticorps bhlhd6, anticorps bhlhd7, anticorps bhlhd8, anticorps xmax2, anticorps xmax4, anticorps xmax, anticorps AA960152, anticorps AI875693, anticorps bHLHd4, anticorps bHLHd5, anticorps bHLHd6, anticorps bHLHd7, anticorps bHLHd8, anticorps fa92b04, anticorps fb52a04, anticorps fb95h11, anticorps wu:fa92b04, anticorps wu:fb52a04, anticorps wu:fb95h11, anticorps zmax, anticorps CG9648 gene product from transcript CG9648-RD, anticorps MYC associated factor X L homeolog, anticorps MYC associated factor X, anticorps Max protein, anticorps MYC associated factor X S homeolog, anticorps myc associated factor X, anticorps Max, anticorps max.L, anticorps MAX, anticorps max, anticorps max.S

Sujet:

Synonyms: Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X, MAX, BHLHD4

Tissue Specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Background: MAX(Max protein), also called Myc-associated factor x, is the most conserved dimerization component of the MYC-MAX-MXD1 network of basic helix-loop-helix leucine zipper (bHLHZ) transcription factors that regulate cell proliferation, differentiation, and apoptosis. The conservation of the MAX sequence is particularly high in the bHLHZ domain, which is involved in protein-protein interactions and DNA binding. The MAX gene is located on chromosome 14q23 by fluorescence in situ chromosomal hybridization. Both quasisymmetric heterodimers resemble the symmetric MAX homodimer, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these 3 evolutionarily related DNA-binding proteins. MAX acts as a classic tumor suppressor gene. Normal lymphocytes from patients showed absence of methylation of the MAX promoter and biallelic expression of MAX, which ruled out an imprinting-mediated effect on MAX expression. The ability of these cells to divide, differentiate, and apoptose in the absence of Max demonstrated for the first time that these processes can occur via Max- and possibly Myc-independent mechanisms.

UniProt: P61244

Pathways: Mitotic G1-G1/S Phases