RTEL1 anticorps (AA 651-756)

N° du produit ABIN5693044

L’anticorps Lapin Polyclonal anti-RTEL1 a été validé pour ELISA et WB. Il convient pour détecter RTEL1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RTEL1 anticorps (AA 651-756) (ABIN5693044)

Antigène: RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RTEL1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-RTEL1 anticorps

Épitope: AA 651-756

Fonction: Anti-RTEL1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-RTEL1 Antibody Picoband® (ABIN5693044). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogène: E. coli-derived human RTEL1 recombinant protein (Position: R651-M756).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Ballew, B. J., Yeager, M., Jacobs, K., Giri, N., Boland, J., Burdett, L., Alter, B. P., Savage, S. A. Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in dyskeratosis congenita. Hum. Genet. 132: 473-480, 2013. 2. Walne, A. J., Vulliamy, T., Kirwan, M., Plagnol, V., Dokal, I. Constitutional mutations in RTEL1 cause severe dyskeratosis congenita. Am. J. Hum. Genet. 92: 448-453, 2013.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur RTEL1

Antigène: RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))

Autre désignation: RTEL1

Sujet:

Synonyms: Regulator of telomere elongation helicase 1

Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Background: The RTEL1 gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 134 kDa

ID gène: 51750