CD2AP anticorps (AA 253-337) (DyLight 488)

N° du produit ABIN7354679

L’anticorps Lapin Polyclonal anti-CD2AP a été validé pour FACS. Il convient pour détecter CD2AP dans des échantillons de Humain.

Aperçu rapide pour CD2AP anticorps (AA 253-337) (DyLight 488) (ABIN7354679)

Antigène: CD2AP (Cd2ap) (CD2-Associated Protein (Cd2ap))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD2AP est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Détail du produit anti-CD2AP anticorps (DyLight 488)

Épitope: AA 253-337

Fonction: Anti-Human CD2AP DyLight® 488 conjugated Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Human CD2AP DyLight® 488 conjugated Antibody -Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogène: E. coli-derived human CD2AP recombinant protein (Position: K253-K337).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Cochran, J. N., Rush, T., Buckingham, S. C., Roberson, E. D. The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Molec. Genet. 24: 6667-6674, 2015. 2. Lowik, M. M., Groenen, P. J. T. A., Pronk, I., Lilien, M. R., Goldschmeding, R., Dijkman, H. B., Levtchenko, E. N., Monnens, L. A., van den Heuvel, L. P. Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation. Kidney Int. 72: 1198-1203, 2007.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Détails sur CD2AP

Antigène: CD2AP (Cd2ap) (CD2-Associated Protein (Cd2ap))

Autre désignation: CD2AP

Sujet:

Synonyms: CD2-associated protein, Adapter protein CMS, Cas ligand with multiple SH3 domains, CD2AP

Tissue Specificity: Widely expressed in fetal and adult tissues.

Background: CD2-associated protein is a protein that in humans is encoded by the CD2AP gene. This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein ly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Poids moléculaire: 39 kDa

ID gène: 23607

UniProt: Q9Y5K6