MDC1 anticorps (AA 534-626)

N° du produit ABIN5693232

Détail du produit anti-MDC1 anticorps

Antigène: MDC1 (Mdc1 (MDC1))

Épitope: AA 534-626

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDC1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for MDC1 detection. Tested with IHC-P, Direct ELISA in Human.

Immunogène: E. coli-derived human MDC1 recombinant protein (Position: A534-Q626).

Information d'application

Indications d'application:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Application Details: Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Détails sur MDC1

Antigène: MDC1 (Mdc1 (MDC1))

Autre désignation: MDC1 (MDC1 Produits)

Synonymes: anticorps 6820401C03, anticorps AA413496, anticorps Nfbd1, anticorps mKIAA0170, anticorps NFBD1, anticorps mediator of DNA damage checkpoint 1, anticorps mediator of DNA-damage checkpoint 1, anticorps Mdc1, anticorps MDC1

Sujet:

Synonyms: Mediator of DNA damage checkpoint protein 1, Nuclear factor with BRCT domains 1, MDC1, KIAA0170, NFBD1

Tissue Specificity: Highly expressed in testis.

Background: Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene. The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

UniProt: Q14676