GSTM1 anticorps (DyLight 488)

N° du produit ABIN5693235

Cet anticorps Souris Monoclonal détecte spécifiquement GSTM1 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour GSTM1 anticorps (DyLight 488) (ABIN5693235)

Antigène: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSTM1 est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Clone: 11F2

Détail du produit anti-GSTM1 anticorps (DyLight 488)

Fonction: Anti-Human GSTM1 DyLight® 488 conjugated Antibody(monoclonal, 11F2)

Séquence: EEEKIRVDIL ,ENQTMDNHMQ LGMICYNPEF EKLK

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Human GSTM1 DyLight® 488 conjugated Antibody (monoclonal, 11F2) (ABIN5693233)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human GSTM1, which shares 70.6% and 73.5% amino acid (aa) sequence identity with mouse and rat GSTM1, respectively.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Carless, M. A., Lea, R. A., Curran, J. E., Appleyard, B., Gaffney, P., Green, A., Griffiths, L. R. TheGSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population. J. Invest. Derm. 119: 1373-1378, 2002. 2. Zhong, S., Wyllie, A. H., Barnes, D., Wolf, C. R., Spurr, N. K. Relationship between theGSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.Carcinogenesis 14: 1821-1824, 1993.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Détails sur GSTM1

Antigène: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Autre désignation: GSTM1

Sujet:

Synonyms: Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GSTM1, GST1

Tissue Specificity: Liver (at protein level).

Background: Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Poids moléculaire: 39 kDa

ID gène: 2944

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity