SCRIB anticorps (AA 172-409) (DyLight 488)

N° du produit ABIN7354660

Cet anticorps anti-SCRIB est un anticorps Lapin Polyclonal détectant SCRIB dans FACS. Adapté pour Humain.

Aperçu rapide pour SCRIB anticorps (AA 172-409) (DyLight 488) (ABIN7354660)

Antigène: SCRIB (Scribbled Homolog (SCRIB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCRIB est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Détail du produit anti-SCRIB anticorps (DyLight 488)

Épitope: AA 172-409

Fonction: Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody (ABIN5693286)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogène: E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. L E Dow, J S Kauffman, J Caddy, A S Peterson, S M Jane, S M Russell & P O Humbert (April 2007). "The tumour-suppressor Scribble dictates cell polarity during ed epithelial migration: regulation of Rho GTPase recruitment to the leading edge". Oncogene. 26 (16): 2272-82. 2. Yi Qin, Christopher Capaldo, Barry M. Gumbiner & Ian G. Macara (December 2005). "The mammalian SCRIB polarity protein regulates epithelial cell adhesion and migration through E-cadherin". JCB. 171 (6): 1061-71.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Détails sur SCRIB

Antigène: SCRIB (Scribbled Homolog (SCRIB))

Autre désignation: SCRIB

Sujet:

Synonyms: Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL

Tissue Specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).

Background: SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.

Poids moléculaire: 39 kDa

ID gène: 23513

UniProt: Q14160

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Tube Formation, Synaptic Vesicle Exocytosis, Asymmetric Protein Localization